Mankhwala "Roncoleukin" ali mgulu la otchuka kwambiri komanso okwera mtengo othandizira chitetezo chamthupi omwe amalipira kusowa kwakukulu kwa amkati interleukin-2, zomwe zimapangitsa kuti zitha kubereka zomwe zimayambitsa zigawo zikuluzikulu. Mankhwalawa, omwe nthawi zambiri amaperekedwa ndi akatswiri owona za ziweto, ndi mawonekedwe komanso magwiridwe antchito a interleukin-2 wamba wamunthu.
Kupereka mankhwalawa
Maselo otchedwa T othandizira, omwe amaimiridwa ndi ma lymphocyte apadera, ndi omwe amachititsa kupanga ma interleukin mthupi.... Mankhwalawa amapangidwa ngati yankho la thupi kuma virus obwera. IL yotulutsidwa imalimbikitsa kupanga kwa T-killers, ndipo nthawi yomweyo kumawonjezera kaphatikizidwe ka zinthu mkati mwa othandizira a T. Makhalidwe apadera a IL ali ndi mphamvu yokhoza kumangika mosavuta kuzipangizo zama cell zama antigen osiyanasiyana omwe amalowa mthupi la anthu osati nyama zokha.
Mankhwala "Roncoleukin" ndi othandiza nthawi zambiri:
- septic zinthu limodzi ndi immunosuppression;
- septic kusintha kwa mtundu pambuyo zoopsa;
- bala matenda pambuyo zoopsa kwambiri;
- dermatitis, dermatoses, chikanga, zilonda zam'mimba;
- mavuto opaleshoni ndi obstetric-matenda;
- kutentha ndi kutentha;
- kufooka kwa mafupa;
- chibayo chachikulu, pleurisy ndi bronchitis;
- Nthawi zambiri kupuma kwamatenda;
- m'mimba matenda ndi peritonitis;
- kapamba necrosis ndi pachimake kapamba;
- chifuwacho chikukula mofulumira;
- khansa kusintha aimpso minofu;
- mavairasi, bakiteriya, mafangasi ndi yisiti.
Chifukwa chake, interleukin imathandizira kwambiri pakupanga maselo oteteza mthupi la nyama, omwe amaimiridwa ndi ma monocyte, macrophages, B ndi T lymphocyte. Mankhwalawa amalimbikitsa mphamvu ya maselo a Langerhans, omwe ndi intraepidermal macrophages.
Ndizosangalatsa! Makhalidwe azamankhwala omwe amagwiritsidwa ntchito ndi "Roncoleukin" amachititsa kuti chiwopsezo chilichonse chololedwa m'thupi la nyama chiwonongeke mwachangu, komanso chimapereka chitetezo chodalirika ku mabakiteriya, mavairasi, yisiti ndi othandizira mafangasi.
Zizindikiro za ntchito ya T-killer imadalira recombinant interleukin-2 (rIL-2), mawonekedwe ndi magwiridwe antchito amkati a interleukin-2. Mwa zina, thunthu kwambiri kumawonjezera kukana kwa thupi kwa ena maselo chotupa, Iyamba Kuthamanga njira kudziwika ndi chiwonongeko wotsatira.
Kapangidwe, mawonekedwe omasulidwa
Immunomodulator "Roncoleukin" ndi njira yabwino yogwiritsira ntchito mawonekedwe a:
- lyophilized ufa njira - 1 ampoule;
- recombinant interleukin-2 kuchuluka kwa 0.25 mg, 0,5 mg ndi 1 mg kapena 250,000, 500,000, kapena 1 miliyoni IU, motsatana.
Omwe amalandira mankhwala osokoneza bongo:
- sodium dodecyl sulphate solubilizer - 10 mg;
- olimba D-mannitol - 50 mg;
- Kuchepetsa dithiothreitol - 0,08 mg.
Katoniyo mumakhala ma ampoules asanu, komanso mpeni wabwino. Unyinji wolimba ndi ufa wa lyophilized, wophatikizidwa mu piritsi loyera kapena lachikasu, losakanizika, losungunuka mosavuta mukamagwiritsa ntchito isotonic sodium chloride solution.
Malangizo ntchito
Masiku ano, pali njira zingapo zogwiritsira ntchito mankhwala amakono opatsirana mthupi, koma mulingo ndi nthawi ya mankhwala ayenera kusankhidwa ndi veterinarian. Mankhwalawa amaperekedwa mozungulira kapena kudzera m'mitsempha, pakadutsa maola 24 kapena 48.
Pafupifupi achire njira ziwiri kapena zitatu jakisoni. Kuwerengera koyenera ndi 10,000 IU / kg. Chithandizo cha matenda a khansa chimaphatikizapo kugwiritsa ntchito jakisoni asanu, ndipo maphunzirowo amabwerezedwa pafupifupi mwezi umodzi. Immunomodulatory "Roncoleukin" amaperekedwanso nthawi kapena pambuyo poizoniyu ndi chemotherapy.
Njira zovomerezeka, zovomerezeka zogwiritsa ntchito mankhwala "Roncoleukin" mu ziweto zamiyendo inayi:
- kugwiritsa ntchito immunomodulator monga katemera wothandizira komanso kuthetsa nkhawa panthawi zosiyanasiyana ndi mlingo umodzi wa 5000 IU / kg;
- Therapy matenda a khungu ikuchitika poika jakisoni atatu kapena asanu pa mlingo wa 10,000 IU / kg;
- Kupewa matenda a bakiteriya, mavairasi ndi mafangasi kumakhudzana ndi kuyendetsa pang'onopang'ono pamlingo wa 5000 IU / kg ngati jakisoni umodzi kapena iwiri yokhala ndi masiku awiri;
- kwa pathologies a kwamikodzo, tikulimbikitsidwa kuti tigwiritse ntchito mankhwalawa ngati majakisoni awiri kapena atatu a 10,000 IU / kg tsiku lililonse;
- aimpso polycystic matenda, mankhwala ntchito zovuta mankhwala mu mawonekedwe a jakisoni asanu a 20,000 IU / kg pa imeneyi ya masiku awiri.
Njira zodzitetezera zimachitika kawiri pachaka pakapita miyezi isanu ndi umodzi... Ndi cystitis ndi urolithiasis, mankhwala opatsirana pogonana amayenera kuperekedwa kudzera mu intravesically kapena intercystially. Njira ya mankhwala imabwerezedwa mwezi umodzi pambuyo pa jakisoni womaliza. Komanso, mankhwala "Roncoleukin" amagwiritsidwa ntchito pokonzekera ziweto zowonetsera. Poterepa, tikulimbikitsidwa kugwiritsa ntchito mlingo wa 5000 IU / kg, womwe umabayidwa kawiri tsiku lililonse, koma jakisoni womaliza ayenera kugwiritsidwa ntchito masiku awiri chionetserochi chisanachitike.
Ndizosangalatsa! Pazochitika zilizonse za kusankhidwa kwa immunomodulator, njira yogwiritsira ntchito iyenera kutsatiridwa, ndipo kuphwanya lamuloli kungayambitse kuchepa kwakukulu kwa mphamvu ya mankhwala.
Immunomodulator "Roncoleukin" imalimbikitsidwa ngati njira yatsopano yothandizira othandizira ziweto zofooka kapena zakale. Pachifukwa ichi, madokotala azipatala azachipatala amapereka mankhwalawo kotala lililonse, ngati jakisoni mmodzi kapena awiri a 5000-10000 IU / kg. Kulimbikitsidwa kwa chitetezo chachibadwa cha ana amphaka omwe ali ndi vuto lofooka loyamwa kumakhudza jakisoni wapakamwa kawiri kapena wocheperako pamlingo wa 5000 IU / kg wokhala ndi tsiku tsiku lililonse.
Zotsutsana
Ngakhale kuti mankhwala "Roncoleukin" nthawi zambiri amalekerera ziweto, zosokoneza nthawi zina zimagwiritsidwa ntchito. Kutsutsana kwakukulu komwe kugwiritsa ntchito mankhwala osokoneza bongo sikuvomerezeka ndi awa:
- ngati chinyama chikulimbana ndi yisiti, chomwe ndi gawo limodzi la mankhwala;
- matenda amadzimadzi;
- pulmonary mtima kulephera kwa digiri yachitatu;
- Pachimake mtima kulephera
- zotupa zaubongo za zovuta zosiyanasiyana;
- mapeto siteji aimpso cell carcinoma;
- nthawi ya mimba.
Nyama zina, hypersensitivity yowopsa imawoneka pamankhwalawa. Mwa zina, mosamala kwambiri, mankhwalawa amapatsidwa amphaka omwe ali ndi mavuto okhudzana ndi impso kapena chiwindi.
Kusamalitsa
Pokonzekera, chiwonkhetso cha nthawi yonse ya mankhwala sichidutsa mphindi zitatu... Njira yothetsera kutetezedwa kwa thupi iyenera kukhala yopanda utoto, yowonekera, yopanda zodetsa zilizonse.
Mankhwala "Roncoleukin" amagwirizana kwathunthu ndi mankhwala ena ambiri. Komabe, mukamagwiritsa ntchito immunomodulator, malamulo osavuta otsatirawa ayenera kutsatira:
- N`zosatheka jakisoni "Roncoleukin" pamodzi ndi njira munali shuga, chifukwa mu nkhani iyi, ntchito zizindikiro za mankhwala ndi zachepa;
- Ndizoletsedwa kupatsa "Roncoleukin" nthawi imodzi ndi mankhwala a corticosteroid ogwiritsa ntchito mwadongosolo kapena kwanuko.
Pakukwaniritsa njira yothandizirayi, tikulimbikitsidwa kuti muzitsatira mosamalitsa miyezo ya veterinarian. Kupanda kutero, poyang'ana chithandizo chomwe chikuchitikacho, kutentha kwa thupi lanyama kumatha kukwera kapena kulephera kwa kugunda kwa mtima kumawonedwa.
Zofunika! Onetsetsani mwatsatanetsatane momwe zinthu zimayendera, komanso chithandizo chamankhwala chokhazikitsidwa ndi veterinarian, popanda kudumpha jakisoni, chifukwa apo ayi mphamvu ya mankhwalayo imachepa kwambiri.
Ndi kuchuluka kwambiri kwa njira yoteteza thupi kumatenda yomwe yalowa m'magazi, zizindikilo za bongo ziyenera kuyimitsidwa ndi mankhwala osokoneza bongo komanso analeptics apadera.
Zotsatira zoyipa
Nthawi yomwe mankhwalawa amagwiritsidwa ntchito mokwanira, ndipo amaperekedwanso kwa chiweto pogwiritsa ntchito njira zovomerezeka, zoyipa sizimawoneka. Subcutaneous jakisoni wa mankhwala "Roncoleukin" nthawi zina amatha kutsagana ndi kumva kuwawa kwakanthawi kochepa ngati "kuyaka".
Ndikuphwanya kwakukulu malamulo ogwiritsira ntchito immunomodulator, atangomaliza kumene, kuwonjezeka kwa kutentha kwa thupi komanso kutentha kwa thupi, komanso kuwonjezeka kosawonekera kwambiri kwa kugunda kwa mtima. Kuchulukitsa kwakukulu kwa mlingowu mukaperekedwa kudzera m'mitsempha kumatha kuyambitsa chiwopsezo kuopseza kapena kufa kwa anaphylactic. Mankhwala osakanizidwa omwe amabayidwa mosavutikira amakhumudwitsa.
Mtengo wa Roncoleukin wa amphaka
Mtengo wa recombinant interleukin-2, mawonekedwe ndi magwiridwe antchito amkati a interleukin-2, olekanitsidwa ndi maselo a yisiti wophika mkate wosakhala ndi tizilombo Saccharomyces servisiae wokhala ndi jini la munthu, ndiotsika mtengo. Mtengo wapakati wa mankhwalawa umasiyanasiyana kutengera kuchuluka kwa zinthu zomwe zilipo ndipo pakali pano:
- 50 zikwi IU - 190-210 rubles;
- 100 zikwi IU - 240-260 rubles;
- 250 zikwi IU - 340-360 rubles;
- 500 zikwi IU - 610-63- rubles.
Tikulimbikitsidwa kuti tithe kugula m'badwo watsopano wa ma immunomodulator m'masitolo ogulitsa ziweto. Mukamagula, onetsetsani kuti mwayang'ana mtundu wa mankhwala, komanso tsiku lomaliza ntchito.
Ndemanga za Roncoleukin
Woteteza kumatenda "Roncoleukin" amalembedwa ndi veterinarians osati ziweto zazikulu zokha, komanso ana amphaka obadwa kumene, nyama zakale komanso zofooka. Mphamvu yayikulu ya mankhwalawa imachokera pakulimbikitsa kwa chitetezo cha mthupi, ndipo chifukwa cha kuchuluka kwa chitetezo, thupi la nyama limalimbana ndi ma virus, mabakiteriya, bowa ndi tizilombo tina tambiri.
Monga momwe ndemanga za eni amphaka zikuwonetsera, milandu yomwe immunomodulator yatsimikizira kuti ndiyabwino kwambiri ndi yosiyana kwambiri.... Chidacho chadziwonetsera bwino pochiza panleukopenia, parvovirus enteritis ndi matenda ena opatsirana, ndipo adziwonetsanso bwino pochiza matenda opuma. Chifukwa cha kugwiritsa ntchito, njira zosinthira zimayambitsidwa ndipo kuchiritsa kwa mabala ovuta komanso osakhalitsa akuchira.
Malinga ndi zomwe awonapo, mankhwalawa amathandiza kuthana ndi chiweto mwachangu ku stomatitis, gingivitis ndi matenda ena am'kamwa, ndizoyenera kuchiza matenda am'mimba (eczema ndi dermatitis), komanso conjunctivitis. Mothandizana ndi mankhwala ena okonzekera kapena mankhwala azitsamba, immunomodulator "Roncoleukin" imangothana ndimatenthedwe ndi chisanu, mabala otupa, komanso ma fracture ndi mikwingwirima yayikulu.
Ndizosangalatsa! Posachedwapa, mankhwalawa akhala akudziwika kwambiri pa nthawi ya katemera ndipo amathandiza kupanga chitetezo chokhazikika ku matenda ofala kwambiri a ma virus.
Mankhwalawa "Roncoleukin", malinga ndi akatswiri owona za ziweto, akutsimikiziridwa kuti apondereze ntchito za zamoyo zambiri zoyipa ndikuwongolera kwambiri kuchira kwa chiweto chamiyendo inayi. Pachifukwa ichi immunomodulator chotere nthawi zambiri chimaperekedwa kuphatikiza ndi mankhwala, zomwe cholinga chake ndi kuthana ndi zomwe zimayambitsa kusintha kwa matenda kapena zizindikiritso zawo.
Zidzakhalanso zosangalatsa:
- Maxidine wa amphaka
- Milbemax ya amphaka
- Pirantel kwa amphaka
- Gamavite kwa amphaka
Pazowona zanyama, mankhwala amtundu wa "Roncoleukin" atha kugwiritsidwa ntchito, monga "Proleukin" ndi "Betaleukin". Komabe, ngakhale ali ndi mphamvu zambiri komanso zosatsutsika, ndi immunomodulator "Roncoleukin" wa m'badwo watsopano wamankhwala, chifukwa chake akatswiri azachipatala samalangiza kupulumutsa thanzi la nyama ndikupatsanso mankhwala amakono kwambiri.
